Molecule discovered that makes obese people develop diabetes

Many people who are overweight or obese develop insulin resistance and type 2 diabetes at some stage in their lives. A European research team has now discovered that obese people have large amounts of the molecule CXCL5, produced by certain cells in fatty tissue.

The main risk factors for type 2 diabetes are obesity and a sedentary lifestyle. The biomedical community has known for many years that substances produced by fatty tissue are responsible for the link between obesity and diabetes. "Chronic inflammation of the adipose tissue, which is characteristic of obese people, is a crucial stage in the development of insulin resistence and type 2 diabetes", Lluis Fajas, lead author of the study and a researcher at the Institute of Health and Medical Research (Inserm) in France, told SINC.

The results of this new study show that serum levels of a chemokine molecule called CXCL5, produced by certain adipose tissue cells, appear at much high levels in the tissues of obese people than in those of individuals with normal weight. This has helped Lluis Fajas's research team to come to a biomedically relevant conclusion: "The CXCL5 molecule helps cause insulin resistance and type 2 diabetes".

The most important part of this study, published in the journal Cell Metabolism, is the discovery that an experimental treatment aimed at inhibiting the action of CXCL5 can help to protect obese mice from develping type 2 diabetes. "If these studies can be confirmed in humans, this treatment would represent a fundamental improvement in the quality of life of obese individuals", the researcher concludes.

Bad habits cause obesity and diabetes

According to the latest data from the Spanish Diabetes Federation (FED), almost 3.5 million people in Spain have diabetes. This illness is most common in Andalusia and Murcia, regions where the highest percentage of people who are obese and sedentary. The specialists agree on the importance of prevention. Avoiding obesity, doing daily physical exercise and giving up smoking are some of the measures that could help to cut the number of diabetes cases by a half.

The International Diabetes Federation (IDF) says that more than 190 million people worldwide currently have diabetes. This figure will rise to 330 million by 2025, due to population growth, the ageing of the population, and increasing urbanisation and sedentary lifestyles. Obesity is the main avoidable risk factor in developing type 2 diabetes. Worldwide, 1.7 billion people are already at high risk of developing a non-contagious, weight-related illness, such as type 2 diabetes.

Obesity can reduce the life expectancy of people with type 2 diabetes by up to eight years, and 80% of people diagnosed with the illness are overweight at the time they are diagnosed.

At least half of all cases of type 2 diabetes among adults could be avoided if they did not put on weight. Taking action on lifestyle, such as changing diet and taking moderate physical exercise, can reduce the risk of developing type 2 diabetes by up to 60%.

Diabetes Nutrition - Make Food Your Ally in the War Against Diabetes

by Debra Wier

One of the crucial components of diabetes management is diet. There is a great deal of opinions as to the best approach when it comes to diabetes nutrition and diets in general. Diets are rarely a one-size-fits-all program so it's a good idea to find one that works for you.

The important thing is to follow a meal plan that suits your personal preferences and lifestyle and at the same time helps you achieve goals for blood glucose, blood pressure, and weight control.

Good Carbs vs. Bad Carbs

It's also a good idea to stay away from or seriously limit the "bad" carbs such as white bread, white rice, and processed foods such as cakes, cookies, potato chips, crackers, candy, and sugary soft drinks.

The G.I. Index

Because "bad" carbs are processed and refined they are assimilated by the digestive system at a much faster pace than "good" carbs. This causes your blood sugar to spike. The faster this action occurs the higher the glycemic index or G.I. value for that food. The slower this action occurs, the lower the G.I. value.

If you were to eat an apple it would take your body a while to convert those carbs into fuel as there are vitamins and fiber the body has to process as well. This is the type of food your body was designed to eat and it is a lower G.I. value food. If you were to eat straight table sugar or "bad" carbs this process would happen at an accelerated pace because the sugar converts immediately. These higher G.I. value foods are simply not the kind of foods our bodies are designed to eat.

How Overeating "Bad" Carbs Can Make Us Fat

When glucose isn't needed right away it is stored in the liver and muscle cells as glycogen.

If the body has too much glucose and all its glycogen storage sites are full, it will convert thisglucose to fat. This explains why it's necessary to watch your consumption of high glycemic foods.

When you consume "bad" carbs you simply aren't giving your body the proper fuel. You wouldn't use the wrong fuel in your car so why put it in your body?

"Good" Fats vs. "Bad" Fats

Another thing that most nutrition experts agree on is watching the "bad" fats in your diet. The "bad" fats are the saturated and trans fats which may increase your risk for developing certain diseases. The saturated fats are fats that are usually solid at room temperature.

The trans fats are the hydrogenated and partially hydrogenated oils found in many processed foods such as crackers, cookies, potato chips, and other processed snack foods.

The "good" fats are the monounsaturated and polyunsaturated fats which help lower disease risk. These are often a good source of omega-3 fatty acids, found mostly in cold-water fish, nuts, seeds, and also in dark leafy greens, flax seed oils and olive oil.

What To Eat

While there is some disagreement regarding the best diabetes nutrition, most experts recommend the following foods:

· Foods with a glycemic index or G.I. rating of 55 or less · "Good" carbs such as whole grains, steel-cut or rolled oats, sweet potatoes, beans, and legumes · Fresh fruit that has a lower G.I. rating · Fresh vegetables · Fish and seafood · Low fat chicken, turkey, and pork · Tofu and egg whites · Low fat or non-fat milk

The Plate Trick

These foods can be the framework of a diabetic diet for excellent diabetes nutrition. The important thing is to make sure that your meals are balanced. An easy way to do this is to mentally picture an imaginary line down the center of your plate. One half of your plate should contain non-starchy vegetables such as spinach, zucchini, peppers, green beans, etc. Now place another imaginary line through the center of the remaining half of the plate. This leaves you with two equal sections. In one section place your "good" carbs such as whole grain breads, potatoes, rice, and pasta. In the remaining section place your protein such as fish, chicken, or turkey. Add some non-fat milk and a small piece of fruit if you so desire.

There you have it; an easy way to keep your diet on target and keep yourself healthy. Use food as your friend to achieve greater health.

About the Author
Debby Wier is an internet marketing specialist who also blogs and writes articles on a wide variety of topics. She believes that every individual should take an active role in their health care to ensure the highest quality of life. Learn more at http://www.123diabeteshealth.com/ a comprehensive

Signs of Diabetes in Women - Cure For Diabetic Symptoms in Women

by Tehmina Mazher

WHAT IS DIABETES? WHY DO WE NEED TO SLASH DOWN OUR SUGAR INTAKE?

Women diabetes is mainly because of obesity. There are different signs of diabetes in women like feeling thirsty, tiredness and dry skin. Most women of the United States of America are suffering from this deadly disease. The excessive indulgences in sift drinks, junk food cause the excessive fats to get piled up on different parts of the body. These fat depositions not only cause the women to look ugly but at the same time the attack of this lethal disease make the situation even worse.
Here are the signs of diabetes in women and the cure for diabetic symptoms:

* Signs of diabetes in women are dry skin, frequent urination, tiredness and recurrent infection. It is recommended to consult doctor if these signs are seen. Aging cause the insulin to become less effective as a result the blood glucose level is disturbed.
* Dieting and exercising helps to cure the diabetes of middle-aged women. One must avoid consumption of sugar as it raises the blood sugar level. The consumption of fats must also be limited. One must avoid the consumption of red meat.
* Regular exercise is a must to cure signs of diabetes in women. Aerobic dances are combination of aerobic exercise and some dances like salsa and jazz. They aid the women to lose weight and cure diabetes. The weight loss helps in controlling the signs of diabetes.
* Middle-aged women must eat leafy green vegetables, fruits and drink plenty of water.
* Keeping the height and weight in proper proportion also help in controlling the signs of diabetes.

So it is not difficult to control the Signs Of Diabetes in women. All a woman has to do is to adopt a healthy lifestyle. You must find here tips and tricks with the help of which I have said "good-bye" to my Diabetes during pregnancy; so you can do the same.

About the Author
I am a gynecologist by profession, married and have a cute little daughter. I love to help diabetics, acne sufferers and pregnant women.

Learn how to control DIABETES

by Joe Lee

Diabetes Control

What is diabetes? Why do we need to slash down our sugar intake?

Many people will become depressed and become sad if sugar is taken out of ALL junk food. Since we all know that diabetes is a life treating condition, we cannot just simply relax and be comfortable about it. Of course nobody wants to suffer from the painful diabetes ending results. Usually, diabetes is due to hereditary and environmental causes resulting abnormally that leads to high blood sugar levels. Diabetes, is a disease that causes the body to metabolize sugar poorly, which occurs when either the body attacks the cells producing insulin, the chemical that allows the metabolizing of sugar in the body's cells also known as (Type 1 diabetes) and the body's cells ignore insulin (Type 2 diabetes).

Types of Diabetes

If you gestational diabetes, you may also need to take medicine to control your blood sugar level. Type 2 diabetes is the most common form of diabetes. Gestational diabetes may occur in women who is age 25 years old or older, but some women have greater risks in developing gestational diabetes. Kidney problems can cause your kidneys to stop working. So be extra careful with your favorite food, though sugar is taste good, but too much of it will make us sick. Either of the 3 types of diabetes, if not properly treated and medicated and if not being implemented regularly may lead to heart attack, eye problems, nerve damage, gum disease, kidney problems and more.

Diabetes Treatment

Eating healthy when you are suffering from diabetes and maintain a balanced diet. Be aware what type of diabetes you have and look for other remedies that will help. Learn to make wise choices for your diabetes care each day. Inculcate self discipline to make you diabetes care plan work.

Alternative Diabetes Cures Through the Herbal Way

When our body malfunctions or suddenly experience any abnormality, it may only conclude that there is something wrong within. Diabetes Mellitus is a disease wherein our pancreas has few or no production of insulin at all. Carbohydrates are considered to be the building block of our body. Aside from the traditional medical treatment you may get a little help from alternative diabetes cures like herbal treatments as well. Insulin maintenance and other medication may only indicate huge medical expenses. Once glucose is being passed thorough our bloodstream, it needs insulin in order to let the glucose to be injected into our cells.

About the Author
The BEST way to find out the truth about diabetes (or even any other disease) is by finding a "real person" (and not some doctor out to take your money so he can drive another Mercedes in addition to the one he already has!) who has successfully overcome the disease and study exactly what "they" did. http://oceans78.DIABETESEZ.hop.clickbank.net

Mediterranean Diet Can Lower Need for Antihyperglycemic Medication in Type 2 Diabetes

Low-carbohydrate and low-fat diets often are recommended for people who have type 2 diabetes and who are overweight. Researchers in Naples, Italy, compared a low-carbohydrate Mediterranean-style diet with a low-fat American Heart Association (AHA) diet in a 4-year randomized trial that involved 215 adults with newly diagnosed type 2 diabetes (not yet on medication), body-mass index >25 kg/m2, and glycosylated hemoglobin (HbA1c) levels <11%. Both diets were rich in whole grains and provided 1500 kcal daily for women and 1800 kcal daily for men. The Mediterranean diet was rich in vegetables and low in red meat (emphasis on poultry and fish), had no less than 30% of calories from fat (30–50 g olive oil daily), and allowed no more than 50% of calories from complex carbohydrates. The AHA diet was restricted in sweets and high-fat snacks and allowed no more than 30% of calories from fat and no more than 10% of calories from saturated fat.

Fewer Mediterranean diet than AHA diet participants required medication to achieve HbA1c levels <7% at 18 months (12% vs. 24%) and at the end of the study (44% vs. 70%). Mediterranean diet participants also had more weight reduction from baseline (by 2 kg) and had greater improvements in levels of HbA1c, fasting plasma glucose, HDL cholesterol, and triglycerides.

Comment: For a lifestyle intervention that many would consider to be quite palatable, a Mediterranean diet produced impressive results — better than those of the commonly prescribed low-fat diet. The results remind us that a pharmaceutical prescription need not be the first reflex when type 2 diabetes is diagnosed.

Diabetic patients face increased risk of bone fractures

Current research suggests that the inflammatory molecule TNF-α may contribute to delayed bone fracture healing in diabetics. The related report by Alblowi et al, "High Levels of TNF-α Contribute to Accelerated Loss of Cartilage in Diabetic Fracture Healing" appears in the October 2009 issue of the American Journal of Pathology.

Diabetes, a condition where the body either does not produce enough, or respond to, insulin, affects at least 171 million people worldwide, a figure that is likely to double by 2030. Long-term complications of diabetes include cardiovascular disease, chronic renal failure, retinal damage that may lead to blindness, nerve damage, and blood vessel damage, which may cause erectile dysfunction and poor wound healing.

Diabetic patients often experience low bone density, which is associated with increased risk of bone fractures and delayed fracture repair. To examine how diabetes affects bone, Dr. Dana Graves and colleagues of the University of Medicine and Dentistry of New Jersey and the Boston University School of Medicine explored bone repair in a mouse model of diabetes. They observed increased levels of inflammatory molecules, including TNF-α during fracture healing. The diabetic animals had rapid loss of cartilage in the healing bones, which was due to increased numbers of osteoclasts, cells that remove bone and cartilage. Factors that stimulate osteoclast formation were regulated by both TNF-α and a downstream mediator, FOXO1. These results suggest that diabetes-mediated increases in TNF-α and FOXO1 may underlie the impaired healing of diabetic fractures.

Alblowi et al suggest that "TNF-α dysregulation plays a prominent role in the recently identified catabolic events associated with diabetic fracture healing." In future studies, Dr. Graves and colleagues plan to "examine the effect of FOXO1 on mineralized tissue to examine how it may regulate factors that control bone resorption and osteoclastogenesis, in addition to effects it may have on osteoblastic cells."

Three cups of tea a day can cut diabetes risk by almost half

Intake of at least three cups of tea every day can reduce the risk of diabetes by almost half, concludes a new study.



To reach the conclusion, researchers studied more than 40,000 people whose consumption was monitored for 10 years.

After analyses, boffins discovered that chemicals found in all types of tea cut the dangers of developing type 2­diabetes by 42 per cent. Drinking more than three cups did not reduce the risk any further, reports The Daily Express.

The study was carried out by a team of Dutch researchers from the University Medical Centre in Utrecht.

The team concluded: "Consumption of at least three cups of tea and/or coffee was associated with a lowered risk of type 2 diabetes. Blood pressure and intake of magnesium, potassium and caffeine did not explain these associations."

Instead, the beneficial effects in tea were probably explained by "flavonoid antioxidants" which are found in every cup.